Centers for Disease Control and Prevention

Division of Parasitic Diseases, Dr. Ya Ping Shi

The mission of the laboratories in Malaria Branch, Division of Parasitic Diseases (DPD) at the Centers for Disease Control and Prevention (CDC) is to conduct investigations on important areas of malaria and to use the information in developing tools for diagnosis, disease control and prevention, and in understanding the mechanisms of biology, immune protection, pathogenesis and drug resistance. Among other projects, Malaria Branch at CDC has developed flow-cytometry based ADCI and GIA for malaria and is also planning a study of ADCI and in vitro correlates of immune protection. Overall, the upcoming ADCI study will be divided into two phases. The first phase will focus on optimization and harmonisation of ADCI, and the second phase is to conduct a cross-sectional matched case-control study in parasitemic and aparasitemic individuals living in Kenya to identify the association between in vitro ADCI function and in vivo protection against malaria.

Material resources: Sample source for the upcoming ADCI project mentioned above will be from the CDC field station in Kisumu, western Kenya, a malaria holoendemic area. The laboratories of Malaria Branch in Atlanta and malaria laboratory of the CDC field station in Kisumu are equipped with modern state-of-the-art equipment, including flow cytometer for carrying out various procedures related to the ADCI project. In addition, the laboratory at CDC field station has a large capacity for sample storage, high quality internet connection and stand-by heavy duty generator for power back-up.

Key persons involved:

Dr. Ya Ping Shi is a senior scientist and the chief of Clinical Immunology and Molecular Epidemiology laboratory at Malaria Branch. She has extensive experience on immunology, vaccine and molecular epidemiology of malaria. She is the PI of the upcoming ADCI project.

Dr. John Barnwell is the chief of Research and Development Unit at Malaria Branch. One of his expertises is in diagnosis and pathogenesis of malaria. He and his group will take part in the laboratory experiments related to the upcoming ADCI project.

Dr. Simon Kariuki is a senior scientist and the chief of Malaria Laboratory of CDC field station in Kisumu. He has extensive experience on malaria immunology and molecular biology. He and his group will take part in laboratory components related to the ADCI project in Kenya.

Dr. Mary Hamel is an epidemiologist and the chief of Malaria Branch of CDC field station in Kisumu. She has extensive field experience and her expertise is malaria epidemiology. She and her group will be responsible for setting up a field system for collection of samples and clinical/epidemiological data related to the ADCI project.

Dr. Laurence Slutsker is a senior epidemiologist and the chief of Malaria Branch of CDC in Atlanta. He will assist in the study design and data interpretation related to the ADCI project from clinical and epidemiological perspective.