Radboud University Nijmegen Medical Centre

Department of Medical Microbiology, Dr. Adrian J.F. Luty

The RUNMC group as a whole currently comprises a multinational assembly of over 20 scientists, including Europeans and Africans, under the leadership and guidance of Professor Robert Sauerwein assisted by a core of very experienced senior scientists. The principal research interests of the group span a broad range of malaria research topics, embracing fundamental research on parasite biology, molecular biology, proteomics, clinical, chemotherapeutic and vaccine-related studies, as well as the epidemiology and immunology of the host-parasite interaction. Research is supported and facilitated by the unique facilities represented by the Malaria Unit that provides parasite material - sporozoites, asexual & sexual stages - as well as infectious mosquitoes that have allowed the group to conduct experimental human malaria infections as well as challenge infections for Phase IIa vaccine studies. The laboratory has independently developed a number of tests for parasitological and immunological evaluation of experimental infections. Phase I/IIa malaria vaccine trials have been carried out at RUNMC in collaboration with industry and EMVI/SSI.

Currently Principal Investigator and Head of the Malaria Unit in the Medical Parasitology Section of the Department of Medical Microbiology, Dr. Adrian JF Luty has extensive experience of project co-ordination including those funded under other EU[INCO] Programmes. Over the last 16 years he has conducted and managed both field- and laboratory-based malaria research projects in sub-Saharan Africa, investigating the evolution of anti-plasmodial immunological responses in neonates and young children and their role in protection from infection and disease due to P. falciparum. His most recent work has focused on cellular immunological aspects of placental P. falciparum infections and the consequent in utero sensitization, revealing the existence of both immuno-regulatory and -stimulatory profiles in neonates with differing exposure to parasite products.